diff --git a/tox.ini b/tox.ini
index 0aed82488..0aa0652e7 100644
--- a/tox.ini
+++ b/tox.ini
@@ -141,6 +141,17 @@ envdir = {[testenv:mkvenv]envdir}
 usedevelop = {[testenv:mkvenv]usedevelop}
 deps = {[testenv:mkvenv]deps}
 
+# Virtualenv with PyQt5 from PyPI
+[testenv:mkvenv-pypi]
+basepython = python3
+envdir = {toxinidir}/.venv
+commands = {envpython} -c ""
+usedevelop = true
+deps =
+    -r{toxinidir}/misc/requirements/requirements-pip.txt
+    -r{toxinidir}/requirements.txt
+    PyQt5
+
 [testenv:unittests-frozen]
 # cx_Freeze doesn't support Python 3.5 yet
 basepython = python3.4